Ductal Carcinoma Signs and Symptoms of Breast Cancer Early breast cancer usually does not cause pain and may cause no symptoms at all. Breast Cancer Statistics Breast cancer ranks second among cancer deaths in women after lung cancer. Risk Factors for Breast Cancer Factors that appear to raise a woman's risk for breast cancer include advancing age, family history, benign breast conditions, and a late menopause. How Is Breast Cancer Diagnosed? It is important to remember that a lump or other changes in the breast, or an abnormal area on a mammogram, may be caused by cancer or by other, less serious problems. Peutz-Jeghers Syndrome People with this syndrome have dark moles around the mouth, nose, and eyes, as well as multiple polyps in the intestines. Li-Fraumeni Syndrome Li-Fraumeni syndrome raises the risk for breast cancer and many other types of cancer. Cowden Syndrome The risk for breast cancer, gastrointestinal cancers, and thyroid cancer is increased with Cowden syndrome, a rare genetic disorder. Ataxia Telangiectasia (A-T) The risk for breast cancer may be increased for women who carry the A-T gene. Ataxia telangiectasia is a rare childhood disease that affects the nervous system and other body systems. Hereditary Breast Ovarian Cancer Syndrome (BRCA1/BRCA2) A woman with this syndrome may develop breast cancer before age 50 and is at higher risk for developing cancer in both breasts or in both the breasts and ovaries.