Overview Melanoma is the rarest, but most virulent, form of skin cancer. Although the incidence of melanoma is lower than other types of skin cancer, it has the highest death rate. Deciding on Treatment Several treatments are available for melanoma—surgery, chemotherapy, and immunotherapy. You will want to discuss with your doctor the benefits and possible side effects of each option. Managing Side Effects Your cancer may cause symptoms, and you will probably have side effects from your treatment. Your health care team will work to ease any side effects that you experience.